Information on new scientific papers on prostate imaging.
This prospective randomized multicenter trial shows the benefits of performing mpMRI of the prostate as a first step in the management of biopsy naïve patients with clinically suspected prostate cancer.
Kasivisvanathan V. and PRECISION Study Group Collaborators. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N Engl J Med. 2018 Mar 18. doi: 10.1056/NEJMoa1801993. [Epub ahead of print] PubMed PMID: 29552975.
Read MoreThis retrospective evaluation shows no difference in diagnostic accuracy between a short 2-sequence MR protocol (T2ax + DWI) and a full mpMRI of the prostate for detection of clinically significant prostate cancer.
Kuhl CK, Bruhn R, Krämer N, Nebelung S, Heidenreich A, Schrading S. Abbreviated Biparametric Prostate MR Imaging in Men with Elevated Prostate-specific Antigen. Radiology. 2017 Jul 20:170129. doi: 10.1148/radiol.2017170129. [Epub ahead of print] PubMed PMID: 28727544.
Read MoreThis prospective, randomised dual-blind study showed an increase in ADC and a decrease in conspicuity of prostate cancer lesions in men undergoing therapy with dutasteride.
Giganti F, Moore CM, Robertson NL, McCartan N, Jameson C, Bott SRJ, Winkler M, Gambarota G, Whitcher B, Castro R, Emberton M, Allen C, Kirkham A. MRI findings in men on active surveillance for prostate cancer: does dutasteride make MRI visible lesions less conspicuous? Results from a placebo-controlled, randomised clinical trial. Eur Radiol. 2017 May 18. doi: 10.1007/s00330-017-4858-0. [Epub
ahead of print] PubMed PMID: 28523355
The study shows an increase in the NPV for exclusion of significant prostate cancer when PSA-Density is included as a parameter into the PIRADS-algorithm.
Distler FA, Radtke JP, Bonekamp D, Kesch C, Schlemmer HP, Wieczorek K, Kirchner M, Pahernik S, Hohenfellner M, Hadaschik BA. The value of PSA density in combination with PI-RADS for the accuracy of prostate cancer prediction. J Urol. 2017 Mar 31. [Epub ahead of print]
Read MoreFirst prospective analysis comparing wbMRI+DWI to bone scan, SPECT, SPECT/CT and 18F-NaF PET/CT for detection of bone metastases in high risk breast and prostate cancer patients.
Read MoreThis recent paper shows an association of T2 Signal Intensity and aggressiveness of prostate cancer in terms of Gleason grade.
Read MoreAgreement between 28 different radiologists from regional hospitals and two subspecialist radiologists in reading prostate MRI was poor. Only in 33% of patients, these two radiologist groups called the same lesions as suspicious for prostate cancer.
Read MoreTwo easily assessed parameters (biopsy history and ADC) may help to triage score-3 lesions into "up for biopsy" or "don't touch but follow).
Read MoreWhile the existing algorithm performs reasonably well, some proposed adjustments to the PI-RADS v2 algorithm may increase the detection of GS≥7 prostate cancer.
Read MoreDCE of the prostate: Intraindividual assessment of the effect of temporal resolution on detection and quantitative analysis of prostate cancer.
Ream JM, Doshi AM, Dunst D, Parikh N, Kong MX, Babb JS, Taneja SS, Rosenkrantz AB. Dynamic contrast-enhanced MRI of the prostate: An intraindividual assessment of the effect of temporal resolution on qualitative detection and quantitative analysis of histopathologically proven prostate cancer. J Magn Reson Imaging. 2016 Sep 20. doi: 10.1002/jmri.25451. [Epub ahead of print] PubMed PMID: 27649481.
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