Two-sequence MR: Enough to detect csPCa?

Two-sequence MR: Enough to detect csPCa?

This retrospective evaluation shows no difference in diagnostic accuracy between a short 2-sequence MR protocol (T2ax + DWI) and a full mpMRI of the prostate for detection of clinically significant prostate cancer. 

Kuhl CK, Bruhn R, Krämer N, Nebelung S, Heidenreich A, Schrading S. Abbreviated Biparametric Prostate MR Imaging in Men with Elevated Prostate-specific Antigen. Radiology. 2017 Jul 20:170129. doi: 10.1148/radiol.2017170129. [Epub ahead of print] PubMed PMID: 28727544.

Read More

Conspicuity of prostate cancer lesions diminished by Dutasteride

Conspicuity of prostate cancer lesions diminished by Dutasteride

This prospective, randomised dual-blind study showed an increase in ADC and a decrease in conspicuity of prostate cancer lesions in men undergoing therapy with dutasteride

Giganti F, Moore CM, Robertson NL, McCartan N, Jameson C, Bott SRJ, Winkler M, Gambarota G, Whitcher B, Castro R, Emberton M, Allen C, Kirkham A. MRI findings in men on active surveillance for prostate cancer: does dutasteride make MRI visible lesions less conspicuous? Results from a placebo-controlled, randomised clinical trial. Eur Radiol. 2017 May 18. doi: 10.1007/s00330-017-4858-0. [Epub
ahead of print] PubMed PMID: 28523355

Read More

PSA-Density: easily obtainable clinical parameter to help excluding significant prostate cancer.

PSA-Density: easily obtainable clinical parameter to help excluding significant prostate cancer.

The study shows an increase in the NPV for exclusion of significant prostate cancer when PSA-Density is included as a parameter into the PIRADS-algorithm. 

Distler FA, Radtke JP, Bonekamp D, Kesch C, Schlemmer HP, Wieczorek K, Kirchner M, Pahernik S, Hohenfellner M, Hadaschik BA. The value of PSA density in combination with PI-RADS for the accuracy of prostate cancer prediction. J Urol. 2017 Mar 31. [Epub ahead of print] 

Read More

Expert readers may reduce overcalling of prostate cancer and minimize negative biopsies.

Expert readers may reduce overcalling of prostate cancer and minimize negative biopsies.

Agreement between 28 different radiologists from regional hospitals and two subspecialist radiologists in reading prostate MRI was poor. Only in 33% of patients, these two radiologist groups called the same lesions as suspicious for prostate cancer. 

Read More

DCE-MRI of the prostate: what's an adequate temporal resolution?

DCE-MRI of the prostate: what's an adequate temporal resolution?

DCE of the prostate: Intraindividual assessment of the effect of temporal resolution on detection and quantitative analysis of prostate cancer.

Ream JM, Doshi AM, Dunst D, Parikh N, Kong MX, Babb JS, Taneja SS, Rosenkrantz AB. Dynamic contrast-enhanced MRI of the prostate: An intraindividual assessment of the effect of temporal resolution on qualitative detection and quantitative analysis of histopathologically proven prostate cancer. J Magn Reson Imaging. 2016 Sep 20. doi: 10.1002/jmri.25451. [Epub ahead of print] PubMed PMID: 27649481.

Read More

Pulse sequences necessary for recurrence detection after Radiotherapy

Pulse sequences necessary for recurrence detection after Radiotherapy

MP MRI of the prostate in detection of recurrent prostate cancer after Radiotherapy: Which sequences are necessary?

Donati OF, Jung SI, Vargas HA, Gultekin DH, Zheng J, Moskowitz CS, Hricak H, Zelefsky MJ, Akin O. Multiparametric prostate MR imaging with T2-weighted, diffusion-weighted, and dynamic contrast-enhanced sequences: are all pulse sequences necessary to detect locally recurrent prostate cancer after radiation therapy? Radiology. 2013 Aug;268(2):440-50

Read More